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鼠曲草黄酮调节脂代谢活性研究.doc

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摘要:目的:研究鼠曲草黄酮对糖尿病小鼠血脂代谢紊乱的改善作用。方法:首先采用腹腔注射链脲佐菌素( STZ )的方法构建小鼠的糖尿病模型,并以盐酸二甲双胍为对照,观察连续灌胃21d不同剂量的鼠曲草黄酮对糖尿病小鼠体重、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)的含量和动脉硬化指数(AI)的影响。结果:鼠曲草黄酮可以明显改善糖尿病小鼠的血脂代谢紊乱情况,显著地降低糖尿病小鼠体内的TG、TC、LDL-C和AI、升高糖尿病小鼠的HDL-C,其中低剂量的鼠曲草黄酮灌胃(100 mg/kg.d)调节血脂代谢效果与盐酸二甲双胍相当。结论:鼠曲草总黄酮具有有效地调节糖尿病小鼠血脂代谢紊乱的活性。  

关键词  鼠曲草黄酮;糖尿病;降血脂

 

Abstract:Objective: The objective of this paper was to study the activities of Gnaphalium Affine Flavonoids on blood lipids in diabetic mice. Method: Diabetes was induced by intraperitoneal injection of streptozotocin in mice. The changes of body weight, TC, TG, HDL-C, and LDL-C, and AI of mice were examined. Results: The blood lipids of diabetic mice were significantly ameliorated by Gnaphalium Affine Flavonoids. Compared with diabetic mice group, the levels of TC, TG LDL-C and AI of Gnaphalium Affine Flavonoids group were significantly decreased, and the level of HDL-C remarkably increased. The effects of improvement induced by high dose Gnaphalium Affine Flavonoids were as same as metformin hydrochloride group. Inclusion: Gnaphalium Affine Flavonoids could effectively ameliorate the levels of blood lipids of diabetic mice.

Keywords  Gnaphalium Affine Flavonoids  Diabetes  Blood lipids

论文资料贡献者对本文的描述:大量研究表明,鼠曲草对很多微生物(包括革兰氏阳性菌、革兰氏阴性菌和真菌)都具有较强的抑制作用。同时还发现,鼠曲草对金黄色葡萄球菌、大肠埃希氏杆菌、枯草杆菌等细菌的......
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